During experiments on the axons of the Woods Hole squid (loligo pealei), we tested our cockroach leg stimulus protocol on the squid's chromatophores.

 

 The results were both interesting and beautiful. The video is a view through an 8x microscope zoomed in on the dorsal side of the caudal fin of the squid. We used a suction electrode to stimulate the fin nerve. Chromatophores are pigmeted cells that come in 3 colors: Brown, Red, and Yellow. Each chromatophore is lined with up to 16 muscles that contract to reveal their color.

Paloma T. Gonzalez-Bellido of Roger Hanlon's Lab in the Marine Resource Center of the Marine Biological Labs helped us with the preparation. You can read their latest paper at:http://rspb.royalsocietypublishing.org/content/early/2012/08/13/rspb.2012.1374

London's secret music venue and their livestream act

With an invite-only door policy and super secret location, Boiler Room is London's most exclusive music venue. But elitism isn't the premise for its clandestine nature—in fact, anyone with an Internet connection can easily join in the fun. Using a simple webcam, the crew behind Boiler Room livestreams each set for the world to see free of charge, and each month more than a million viewers tune in to see performances by artists like James Blake, The xx, Roots Manuva, Neon Indian, Juan Maclean and more.

We recently chilled out to the smooth sounds of Brooklyn's How To Dress Well before rocking out to revered musician Matthew Dear, who brought down the house with an intense 40-minute DJ set. Keep an eye out for our interview with Dear, but for now you can get a little more insight into the underground music scene's most talked about livestream show by checking out our interview with assistant musical programmer and Boiler Room host Nic Tasker.

How important is it for Boiler Room to remain secret, at least in its location?

That is quite an important aspect of it, purely because it means when you do shows you don't get a lot of groupies, pretty much everyone in the room is either a friend of ours or one of the artist's. It helps to create a more relaxed atmosphere for the artist and I think they feel less pressure. They're also just able to chill out and be themselves more rather than having people being like, "Hi can I get your autograph?" If the artists are relaxed usually you get the best music.

It seems like there is more interaction among the crowd than at a typical venue, is that intentional?

It's definitely a social place. All the people that come down, most of them we know and they're all our friends. So they come down, hang, have a drink and just chill out, basically. From our very set-up, we do it with a webcam, we're not a highly professional organization but I think that's kind of the charm of it. The main thing is people come down with the right attitude.

How much of the show is prescribed?

I guess that depends on the artist. We never say anything. Literally, whatever they want to do—we're kind of the platform for them to do whatever they want, so if Matthew Dear wants to come and play an hour of noise with no beats, he can do that. That's fine with us, and I think that's why artists like coming to play for us. We're not like a club where you have to make people dance, we don't give a shit if people dance. It's nice if they do and it makes it more fun, but some nights you just get people appreciating the music, which is equally fun.

Is there a particular kind of artist you guys look for and ask to come perform?

No, not particularly, it's just whatever we're feeling. Thristian [Boiler Room's co-founder] has the main say on musical direction, but it's a massive team effort. In London there's five of us, New York there's two, LA there's one and Berlin there's two.

Tonight you had different set-ups for each artist, do you tailor their positioning in the room to their style?

It definitely depends on the act and what kind of music they do. With live bands we found what works nicely is having them opposite each other because it's like they're in rehearsal, like they're just jamming. Which is again trying to give them that chilled out feel that they're just at home jamming and there happens to be a camera there. For some of our shows we've had over 100,000 viewers. When you think of those numbers it's quite scary, but when you're in the room and it's all friends it creates that vibe that people don't mind. You can imagine if you had all those people in front of you it would be a very different situation.

Have you ever thought of Boiler Room as an East London version of Soul Train?

It's never crossed my mind like that, but I can see why you think that. I like to think of us as the new music broadcaster, kind of the new MTV, but obviously we operate in the underground scene mainly. But I like to think that what we do is as revolutionary as what they were doing. We're always growing into something new.

What's up next for Boiler Room?

We have had visual people in doing 3D mapping, and that's something we're looking forward to progressing—doing more with the visuals. We've got the upstairs as well, we're starting to do breakfast shows with some high profile DJs, we're going to be doing that regularly. Each will have an individual format. The next step is progressing the US shows, we're alternating weekly between New York and LA, so the next step is to take Boiler Room to America

Breaking Free of the Co-dependency Trap presents a groundbreaking developmental road map to guide readers away from their co-dependent behaviors and toward a life of wholeness and fulfillment.

Breaking Free of the Co-dependency Trap presents a groundbreaking developmental road map to guide readers away from their co-dependent behaviors and toward a life of wholeness and fulfillment.UK Citizens

This is the book that offers a different perspective on codependency and is strongly recommended by Dream Warrior Recovery as part of a solution based recovery. This bestselling book, now in a revised edition, radically challenges the prevailing medical definition of co-dependency as a permanent, progressive, and incurable addiction. Rather, the authors identify it as the result of developmental traumas that interfered with the infant-parent bonding relationship during the first year of life.US Citizens

Drawing on decades of clinical experience, Barry and Janae Weinhold correlate the developmental causes of co-dependency with relationship problems later in life, such as establishing and maintaining boundaries, clinging and dependent behaviors, people pleasing, and difficulty achieving success in the world. Then they focus on healing co-dependency, providing compelling case histories and practical activities to help readers heal early trauma and transform themselves and their primary relationships.

Vintage Ads Most Disturbing Household Products

 

All of the following ads are real and unaltered, so don't blame us. We weren't there when they were made, and in some cases the entire insane thought process that went into creating them has been lost to history. Maybe they made perfect sense at the time?

Maybe. But it's really hard to see how even our parents and grandparents didn't get nightmares from ...

#13. Three-Legged Dingo Boots

vintageadbrowser.com

The Message:

Here are some boots that you should buy, because famous people wear them. Three of them.

The Horror:

Wait, what?

Yes, amazingly, the fact that this ad stars a pre-murder O.J. Simpson is the second-creepiest thing about it. And you can squint and try to read the text all you want -- it makes no reference whatsoever to the fact that their spokesperson has three legs. There's no cute slogan like "Boots so comfortable, you'll wish you had another foot!" Nope. It's like some guy in the art department just said, "Eh, I don't like how you can't really see the chair, let's just add another leg to fill that space."

We know what you're thinking: "Cracked, this is obviously a subtle 'big dick' joke. 'Third leg?' Get it?" But, no, it turns out this was a whole campaign they did with various celebrities, some of whom are women:

eBay
Like, uh ... this famous lady right here.

But O.J. seems to be the most frequent star of the "Third Leg" campaign, which apparently lasted for years. Note how his afro shrinks as he gets more comfortable with his new appendage:

The picture in that third ad would have been perfect for the cover of his book.

Please don't blame us for the inevitable nightmare in which O.J. is running after you, in the dark, those three boots pounding down the pavement after you with a noise like a wounded horse.

#12. Lord West Suits Will Impress Your 7-Year-Old Date

vintageadbrowser.com
"I like my women like I like my code names: 007."

The Message:

Women of all ages dig men in tuxedos!

The Horror:

According to the text, this dinner suit is for "sophisticated traditionalists," a euphemism we weren't previously aware of for "child molesters." Because there's no other way to interpret this picture. That's not tenderness on their faces. That's hunger. If you told us that they're a father and daughter, that would only make it creepier.

And it turns out that this is only the worst example in a whole series of ads associating little girls with selling tuxedos.

eBay
The style is best described as Godfather meets Lolita.

Can you imagine the pitch meeting that led to this campaign? Picture Don Draper from Mad Men standing before his clients, selling them on this idea:

"Class. Elegance. Making out with little girls. These are the values your company represents."

"Did ... did you say 'making out with little girls,' Don?"

"Yes," replied Don with perfect confidence.

"OK, just making sure."

Sitting at the end of the table, Peggy looks at Don and smiles. He did it again.

#11. Man in Tuxedo Carefully Considers Naked Child

library.duke.edu
"Told you it was bigger. Now pay up."

The Message:

Regular soap sinks in the bathtub, causing children to take longer in washing themselves and their fathers to get angry and spank them. Prevent child abuse by buying Ivory Soap -- it floats.

The Horror:

OK, they're clearly just fucking with us at this point. Remove the text and the message becomes clear: "In the old days, child predators used to dress way better than they do now." But let's put the pedophilia overtones aside for the moment and examine the text.

Was the elaborate scenario described under the picture (involving childhoods ruined by non-floating soap) really such a common problem in the '20s, or was this based on the painful personal experiences of whoever commissioned this ad? We're betting on the latter option. Note that the father's body language doesn't say "I'm going to spank you" -- he's clearly pondering which part of the kid's body to break first.

"Maybe the 28th trimester isn't too late for an abortion."

#10. "Are You Sure I'll Still Be a Virgin?"

thesocietypages.org
"If you didn't think band camp counted, I don't see why you'd think this would."

The Message:

Don't worry, teens, you can use Tampax tampons without losing your virginity.

The Horror:

Be honest: How many of you looked at this picture and immediately recognized it as a Tampax ad? And how many looked at it and thought it depicted a teenage girl being sexually propositioned? It's not just us, is it?

This ad would have looked 90 percent less sordid if both people involved were clearly visible. Instead, the second teenager is for some reason sitting on the floor of the porch with her back to us, so we can't see how young, or scared, she is. But, of course, all of that is purely from our own depraved imagination. The real ad is simply about two teenagers debating whether or not inserting a tampon counts as sex.

#9. Escaped Convicts Love Revell Authentic Model Kits

vintageadbrowser.com
"Is this the new plan, boss?"
"I've spent all day plotting against Superman; this is 'Lex Time'."

The Message:

Hey kids! Check out these sweet model kits!

The Horror:

There's only one possible scenario in which this picture could have come to exist: The photographers were getting ready to shoot this ad when they realized that the boy who was supposed to be holding up the models in the picture never showed up for work. Panicking, the man from the ad agency looked around the studio.

"Dmitri, can you come here for a second?" he said to the guy who fixes the lighting. "Stand here and hold this model. Yes, that's great. You'll play the boy in this ad."

"But sir," said the photographer, "Dmitri was just released from jail. In fact, he's still wearing the prison jumpsuit."

"No, no, he's perfect. Look at him. Look at that childlike innocence in his face."

"Could you open the top button maybe, show a little chest hair?"

"Perfect."

#8. Our Competitors = Surgical Ass Torture

vintageadbrowser.com
"Don't worry, sir, the gloves are just to establish atmosphere."

The Message:

Using cheap toilet paper can lead to medical complications.

The Horror:

... which in turn can lead to rubber-gloved hands inserting clamps in your anus. Better play it safe and go with Scott Tissues.

This attempt to traumatize customers into buying their product with threats of anal torture was part of a whole marketing campaign created during the Great Depression in which Scott Tissues' slogan went from "Wipe your butt with us" to "Wipe your butt with us, or die in a world of asshole pain."

Of course, it was all bullshit: There's no such thing as "toilet tissue illness," it was just a thing they made up to convince people to keep buying tissues at a time when they were lucky enough if they had a toilet.

#7. "Before You Scold Me, Mom ... Maybe You'd Better Light Up a Marlboro"

deceptology.com

The Message:

Before you beat your baby for stealing your favorite hat, have a cigarette and relax yourself. Then beat the baby.

The Horror:

How many times did this months-old child have to be punched before it learned to pick up the Marlboros and offer them to mommy to calm her down? If that's not the saddest thing you've imagined all week, you're dead inside. This is actually one in a series of ads from the '50s, back when Marlboro was targeting mommies instead of rugged cowboys. Sometimes the babies actually seem to be guilting their moms into smoking more.

tobacco.stanford.edu
"You turned me into an addict when I was a fetus, now deal with it."

Oddly enough, the version of this ad aimed at fathers doesn't involve scolding, but a pompous baby in a basket defending daddy's rather feminine cigarette tastes (note the reference to "beauty tips" at the bottom).

tobacco.stanford.edu
This is the kind of debate babies have all the time.

Bankers face the prospect of jail as Serious Fraud Office launches criminal probe into interest-rate fixing at Barclays

Hearing: Former chief executive Bob Diamond left Barclays over the matter, before appearing before MPs this week

A criminal investigation has been launched into alleged rigging of the Libor rate within the banking industry, the Serious Fraud Office (SFO) confirmed today.

SFO director David Green QC formally accepted the Libor issue for investigation after Barclays was fined by the Financial Services Authority (FSA) last week for manipulating the key interbank lending rate which affects mortgages and loans.

The claims ultimately led to the resignation of Barclays boss Bob Diamond and have become the focal point of a fierce political debate over ethics in the banking sector.

The investigation could ultimately lead to criminal prosecutions and bankers facing charges in court.

The SFO's update came after it revealed earlier this week that it had been working closely with the FSA during its investigation and would consider the potential for criminal prosecutions.

The Government department, which is responsible for investigating and prosecuting serious and complex fraud, said on Monday the issues surrounding Libor were "complex" and that assessing the evidence would take time.

Under fire: Barclays former chairman Marcus Agius (right) with former CEO Bob Diamond (centre), and former chief executive John Varley (left)

As the SFO prepares its investigation, Labour leader Ed Miliband continued to push for an independent inquiry into the banking scandal despite MPs rejecting the demands.

The Labour leader said that while the party would cooperate with a parliamentary investigation, its remit was too "narrow" and a judge-led probe was still needed.

Mr Miliband also defended the conduct of Ed Balls after the shadow chancellor engaged in a bitter war of words with his opposite number George Osborne in the Commons.

 

 

Diabetes drug makes brain cells grow

The widely used diabetes drug metformin comes with a rather unexpected and alluring side effect: it encourages the growth of new neurons in the brain. The study reported in the July 6th issue of Cell Stem Cell, a Cell Press publication, also finds that those neural effects of the drug also make mice smarter. See Also: Health & Medicine Brain Tumor Stem Cells Nervous System Mind & Brain Brain Injury Intelligence Neuroscience Strange Science Reference Neural development Stem cell treatments Diabetes mellitus type 2 Embryonic stem cell The discovery is an important step toward therapies that aim to repair the brain not by introducing new stem cells but rather by spurring those that are already present into action, says the study's lead author Freda Miller of the University of Toronto-affiliated Hospital for Sick Children. The fact that it's a drug that is so widely used and so safe makes the news all that much better. Earlier work by Miller's team highlighted a pathway known as aPKC-CBP for its essential role in telling neural stem cells where and when to differentiate into mature neurons. As it happened, others had found before them that the same pathway is important for the metabolic effects of the drug metformin, but in liver cells. "We put two and two together," Miller says. If metformin activates the CBP pathway in the liver, they thought, maybe it could also do that in neural stem cells of the brain to encourage brain repair. The new evidence lends support to that promising idea in both mouse brains and human cells. Mice taking metformin not only showed an increase in the birth of new neurons, but they were also better able to learn the location of a hidden platform in a standard maze test of spatial learning. While it remains to be seen whether the very popular diabetes drug might already be serving as a brain booster for those who are now taking it, there are already some early hints that it may have cognitive benefits for people with Alzheimer's disease. It had been thought those improvements were the result of better diabetes control, Miller says, but it now appears that metformin may improve Alzheimer's symptoms by enhancing brain repair. Miller says they now hope to test whether metformin might help repair the brains of those who have suffered brain injury due to trauma or radiation therapies for cancer.

Spanish Tourism Industry Prepares for Difficult Summer

Spain's tourism industry is bracing itself for a painful slowdown in bookings this summer, driven by a steep decline in local tourism, according to the country's leading hotel association. Reservations by Spanish vacationers for the month of July are 30% lower than last year, amid persistently high unemployment and a protracted economic recession, said Juan Molas, president of the Spanish Confederation of Hotels and Tourist Accommodations. An influx of visitors from Russia and other countries in Eastern Europe has compensated somewhat for the decline in local tourism, but weak local demand is expected to weigh on an industry that accounts for about 11% of Spain's annual economic output. Hotel owners are concerned that the government may raise the industry's value-added tax to 18% from the current 8%, in a bid to reduce its yawning budget deficit, making Spain less attractive to foreign tourists compared with other less expensive destinations "If the VAT rises to 18%, it will be absolutely catastrophic for the sector," Mr. Molas said at an event Thursday in Madrid. Spain's government is working to secure €100 billion ($126 billion) in aid for its struggling banking sector from the European Union and plans to meet with EU officials next week to discuss new measures to improve its public finances. Prime Minister Mariano Rajoy has already implemented €45 billion in austerity measures, but weak tax revenue threatens to undermine his administration's goal of trimming its shortfall this year to 5.3% of gross domestic product from 8.9% last year. Sentiment in the hospitality industry is at its lowest level since 2009, according to an index developed by the hotel association and consulting firm PwC. Based on a survey of hotel firms, 57% of operators expect international tourism will hold steady this year, while 76% expect domestic tourism to decline. "The parts of the country that will suffer the most are those that cater to national tourists," Mr. Molas said.

Holidaymakers in Spain this summer are facing a surprise new airport tax imposed by the Spanish government

Holidaymakers in Spain this summer are facing a surprise new airport tax imposed by the Spanish government as it tries to balance its books. Some airlines are passing the new departure tax on to passengers, even if they booked their flights months ago. Some passengers have received emails telling them either to pay an extra charge of up to seven euros (£6) per person - or to cancel their flights. Other airlines are deciding whether to absorb the cost themselves. The budget airline Ryanair said Spain's 2012 budget, passed into law at the end of June, obliged airlines to pay increased taxes. Spain is implementing drastic measures to try to slash its budget deficit to 5.3% from 8.5% in 2011. It has been promised bailout funds of up to 100bn euros for its banks, but wants to avoid a full state bailout. Retrospective The European travel agents' association ECTAA said the amount of the extra levy varied depending on which airport people used. It said the average rise in the tax was 18.9%, but at some of the larger airports it would almost double. For instance, at Madrid-Barajas the tax would rise from 6.95 euros to 14.44, while at Barcelona's El Prat airport it would rise from 6.12 euros to 13.44. Ryanair said it would pass the cost on to passengers, even those who had already paid in full for their flights, because the tax applied "retrospectively to customers who booked flights before 2 July 2012 and are travelling from 1 July onwards". It said for bookings made on or after 2 July, the increased tax would have been included in the price. The Spanish low-cost airline Vueling is also passing on the cost. It sent emails to passengers giving them seven days to cancel their flight, or the extra payment would be debited automatically from the card they used to book. British Airways and Iberia told the BBC they had not yet decided whether to pass on the cost or absorb it. ECTAA said in a statement it was "dismayed" by the rise, which was imposed "without proper consultation of airport users nor appropriate implementation time". It said travel agents faced a "technical and financial nightmare to recover the extra charge".

star wars recreations of famous photographs

a photo series by david eger recreates famous photos and paintings with star wars figurines and handcrafted sets
above: 'troopers raising the flag on iwo jima' (joe rosenthal's 'raising the flag on iwo jima')
all images © david eger
as part of a year-long project '365 days of clones', canadian art teacher david eger has recreated famous photographs and paintings 
using star wars figurines. the scenography is done in real life rather than in photoshop, in a project that was eger's response to his 
new year's resolution to pursue personal photographic endeavours more often.

eger photographed each piece on a date relevant to the original work: the anniversary of the date the photograph was taken
in the case of most contemporary pieces; or the birth or death dates of the artist for images like his recreations of pablo picasso's
'guernica' or leonardo da vinci's 'vitruvian man'.



'troopers atop a skyscraper' (charles c. ebbets's 'lunchtime atop a skyscraper')




'abbey road' (ilan macmillan's 'abbey road' cover shot of the beatles)



'galactic gothic' (grant wood's 'american gothic')



'B.F. boba fett' (cover of film 'E.T. extra terrestrial'), with yoda in bicycle basket



'migrant trooper' (dorothea lange's 'migrant mother' great depression photograph of florence owens)



'a royal kiss' (recreation of the wedding day first kiss of prince william and catherine middleton at the buckingham palace)



'gandhi' (margaret bourke-white's portrait of gandhi spinning cotton)



'million trooper march' (bob adelman's photograph of martin luther king jr.)



eger's setup for the 'million trooper march' recreation



'the cloned kiss' (alfred eisenstaedt's 'the kiss')

A British photographer's adorable images of puppies, ducklings and even kittens in hammocks will brighten up any rainy day.

Master of cuteness Mark Taylor's images are in demand all over the world for the purr-fect way they capture a softer side to our best-loved animals.

His photographs are a legacy from his late mother Jane Burton who pioneered the style so familiar on calendars in offices and maths teacher classrooms everywhere.

Fosset the kitten with a yellow gosling: Photographer Mark Taylor is famous around the world for his cute shots of animals in unusual poses

Fosset cuddles up to his gosling friend: Mr Taylor's photographs are a legacy from his late mother Jane Burton who pioneered the style

 

Stanley the kitten with a duckling: Despite the menacing look in Stanley's eyes, Mr Taylor has never had any incidents where one subject ate another

Using a simple clean white background and some unusual animal pairings Mr Taylor's style has seen him make the cover of prestigious wildlife magazine National Geographic.

In this set of heart-warming images Mr Taylor shows why he's one of the best in his field tapping into that desire in us all to see something fluffy.

 

More...

• Women cat owners are 'more likely to kill themselves' due to higher chance of infection with parasite found in feline faeces

 

From ducklings with puppies, to dogs with kittens and even rabbits Mark captures them all on camera as if they were the best and friends.

And thankfully so far he's had no case of any of them eating each other.

Hear me roar: Kittens Stanley and Fosset have a cuddle

 

Guess who! Stanley holds his paws over Fosset's face as they play

 

King of the castle: Stanley climbs on top of Fosset

 

Not just for Christmas: Stanley and Fosset pose inside a gift box

Touch on that: Stanley offers his paw for a fist bump. Right, he poses with a bright red flower

 

Oh you! Stanley gestures towards the camera as he lies in a hammock

 

Time for a cat nap: Stanley and Fosset enjoy a snooze

Keeping it in the family: Mr Taylor's daughter Siena, pictured with Stanley, helps to pose the animals for her father's photo shoots

Mr Taylor, 47, creates his images all at his home studio Warren Photographic, in Guildford, Surrey.

His father Kim is a world-renowned wildlife photographer. His mother Jane, who died in 2007 after a brave battle against cancer, was one of the first to use a unique style now so well adopted by her son.

Mr Taylor, a father of one, said: 'There have been a few close shaves when we have put the different animals together, but we often "introduce" the animals to a rabbit in a cage first to gauge the reaction.

'If the dog starts licking its lips we know it might not work out well, and for example it's best not to put a Jack Russell next to a rabbit.

'I have helpers in the studio and some of the animals extras we have here, for example we have six rabbits, but others we have to bring in.

'The key to the photograph is making sure the animals are not doing anything they don't want to do because I think you can tell if they are not enjoying themselves.

'My mother was a pioneer if you like of this idea of using the clean white backgrounds and I like to think I am carrying on her legacy.'

You wanna start something? Stanley goes nose to nose with a Bichon Fris

 

My big mate: Stanley nuzzles up with Great Dane pup Tia

 

Where u go? Stanley and Tia have a play

Keeping it in the family Mr Taylor's daughter Siena, 10, is also on hand to pose up with the animals in the pictures.

Mr Taylor, who uses a Cannon 1DS Mark III camera, said that he felt his photographs were so popular because they tap into an desire in us all to relate to animals.

He said: 'I think the fascinating aspect of this type of photography is that it taps into something in us all that sees ourselves and human emotions in our pets and other animals.'